Professional Supplier L-1-Phenylethylamine (S) - (-) -Alpha-Methylbenzylamine CAS 2627-86-3

• Customization: Available
• CAS No.: 2627-86-3
• Formula: C8h11n
• Model NO.: 99%
• Type: Synthesis Material Intermediates
• Appearance: Liquid
• Quality: Industrial
• Colour: Colorless
• Specification: ≥ 99%
• Trademark: JinYu
• Origin: China

Product Description

Product Description

(S)-(-)-α-Methylbenzylamine
(S)-(-)-α-Methylbenzylamine is a chiral organic compound widely used as a pharmaceutical intermediate and in asymmetric synthesis due to its optical activity and amine reactivity. Here's a detailed overview:

Basic Information

• Chemical Formula: C8H11N
• Molar Mass: 121.187 g/mol
• CAS Number: 2627-86-3
• Other Names:
  • (S)-(-)-1-Phenylethylamine
  • L-(-)-α-Phenylethylamine
  • (S)-1-Amino-1-phenylethane
• Structure: Features a chiral α-carbon atom (attached to a methyl group, phenyl ring, amino group, and hydrogen), giving rise to its optical activity.

Physical Properties

• Appearance: Colorless transparent liquid with an amine-like odor.
• Melting Point: -10 °C
• Boiling Point: 187-189 °C (at 1 atm)
• Density: 0.94 g/mL at 25 °C
• Refractive Index: nD20 = 1.525-1.527
• Flash Point: 79 °C (closed cup)
• Solubility: Slightly soluble in water; miscible with organic solvents like ethanol, diethyl ether, and chloroform.
• Optical Rotation: [α]D20=−40° (neat, pure liquid), indicating left-handed (levorotatory) rotation of plane-polarized light.

Chemical Reactivity

1. Amine Chemistry:
   • Acts as a nucleophile in reactions such as acylation, alkylation, and condensation.
   • Forms salts with strong acids (e.g., hydrochloric acid), which are often crystalline and used for purification.
2. Chiral Resolution:
   • Serves as a chiral resolving agent for separating racemic mixtures (e.g., in the synthesis of pharmaceuticals like amphetamines or anti-inflammatory drugs).
3. Asymmetric Synthesis:
   • Introduces chirality in organic reactions, particularly in the preparation of enantiomerically pure compounds.

Applications

1. Pharmaceutical Industry:
   • Key intermediate in synthesizing chiral drugs, such as:
     • Antidepressants (e.g., selective serotonin reuptake inhibitors, SSRIs).
     • Anti-Parkinson's medications.
     • Beta-blockers for cardiovascular diseases.
2. Organic Synthesis:
   • Used in the preparation of chiral ligands, catalysts, and auxiliaries for asymmetric reactions (e.g., aldol reactions, Michael additions).
3. Research and Development:
   • A model compound for studying chiral recognition and stereoselective reactions in organic chemistry.

Safety and Handling

• Hazard Class:
  • Corrosive (C): Causes severe skin and eye burns (Risk Code R35).
  • Toxic if absorbed through skin or ingested (R21/22).
• Safety Measures:
  • Personal Protection: Wear chemical-resistant gloves, safety goggles, and a lab coat. Use a fume hood to avoid inhalation of vapors.
  • First Aid:
    • Skin/Eye Contact: Flush immediately with plenty of water for 15 minutes; seek medical attention.
    • Inhalation: Remove to fresh air; provide respiratory support if needed.
    • Ingestion: Do not induce vomiting; give water or milk and consult a physician.
• Storage: Store in a tightly sealed container in a cool, dry place, away from incompatible substances (e.g., strong acids, oxidizing agents).
• Transport: Classified as a corrosive substance (UN2735, Category 8).

Environmental Considerations

• Toxicity: Moderate toxicity to aquatic life; avoid release into waterways or soil.
• Biodegradability: Limited data, but amine-containing compounds may undergo microbial degradation in aerobic environments.
• Disposal: Dispose of as hazardous waste following local regulations; incineration may be required for large quantities.

Product Parameters

 

Packaging & Shipping

Liquid products	Drum of 5kg ,10 kg ,25 kg ,50 kg 200 kg ,250 kg . 1000 kg IBC drum. TANK with 20 tons ,25 tons .
Solid products	Bag of 1 kg ,2 kg ,5 kg ,25 kg ,500kg ,1000 kg . Drum of 25 kg and 50 kg.

Packaging can be customized according to customer requirements.

Company Profile

Qingdao Jinyu Chemical Co., LTD,which is located in Qingdao City, China, with registered capital of RMB 10 million, is a dynamic chemical import and export enterprise with customer demand as its own responsibility. The founder has been engaged in the chemical industry for more than 20 years. With professional technical and marketing personnel, diversified cooperative factories with synthetic technology and efficient logistics management, we provide services to customers all over the world. After years of hard work, we have selected a number of excellent chemical production cooperative enterprises in China. These enterprises have their own advantages in different chemical synthesis fields. They have passed the strict inspection of suppliers by many customers and formed a long-term and stable strategic partnership with customers. With our partners' excellent equipment, well-trained employees and mature technology, we also continue to provide customers with more products.

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