| Customization: | Available |
|---|---|
| CAS No.: | 39537-23-0 |
| Formula: | C8h15n3o4 |
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Basic Information
Product Name: L-Alanyl-L-Glutamine
Chemical Formula: C8H15N3O4
Molecular Weight: 217.22
CAS Registry Number: 39537-23-0
Appearance: White crystalline powder
Melting Point: 253-260°C
Boiling Point: 615.4°C at 760 mmHg
Refractive Index: 10° (C=5, H2O)
Density: 1.305
Solubility: Soluble in water
Physiological Functions
Glutamine Supplementation: Glutamine is the most abundant non-essential amino acid in the human body. In catabolic and hypermetabolic states, the body's demand for glutamine increases. Exogenous supplementation of L-alanyl-L-glutamine can be rapidly decomposed into glutamine and alanine in vivo, providing glutamine for the body.
Intestinal Barrier Maintenance: Glutamine serves as the primary energy source for intestinal mucosal cells, helping maintain the integrity of the intestinal mucosa, preventing bacterial translocation, and reducing the risk of intestinal infections.
Immune Function Enhancement: Glutamine participates in the proliferation and differentiation of lymphocytes, playing a crucial role in maintaining normal immune system function. It enhances the body's resistance and reduces the incidence of infections.
Protein Synthesis Promotion: It provides amino acid building blocks for protein synthesis, aiding muscle protein anabolism and reducing muscle protein catabolism. For patients in hypercatabolic states (e.g., trauma, burns, post-surgery), it helps maintain muscle mass and physical function.
Clinical Applications
Parenteral Nutrition Support: For patients unable to meet nutritional needs orally (e.g., severe pancreatitis, short bowel syndrome, gastrointestinal obstruction), L-alanyl-L-glutamine can be used as a component of parenteral nutrition, administered with other amino acid solutions or amino acid-containing infusions.
Burns and Trauma Patients: Burned or traumatized patients are in a hypercatabolic state with increased glutamine consumption. Supplementation improves nutritional status, promotes wound healing, and reduces infectious complications.
Critically Ill Patients: In intensive care unit patients, stress responses significantly increase glutamine demand. Supplementation improves nitrogen balance, enhances immunity, and reduces infection rates and mortality.
Cancer Patients: During chemotherapy or radiotherapy, cancer patients often experience gastrointestinal adverse reactions, leading to insufficient nutrition intake and increased body consumption. L-alanyl-L-glutamine alleviates gastrointestinal symptoms, improves nutritional status, and enhances tolerance to chemo/radiotherapy.
Precautions
Contraindications: Contraindicated in patients with severe renal insufficiency (glomerular filtration rate <25 ml/min) or severe hepatic insufficiency.
Administration: Dosage and duration should be determined based on the patient's condition, body weight, and nutritional needs. Typically, the recommended daily dose for adults is 0.3-0.5 g/kg body weight, administered via intravenous infusion in combination with other amino acid solutions.
Drug Compatibility: Compatibility issues may occur when mixed with other drugs. Always refer to the medication guide carefully to avoid incompatible combinations.
| Liquid products | Drum of 5kg ,10 kg ,25 kg ,50 kg 200 kg ,250 kg . 1000 kg IBC drum. TANK with 20 tons ,25 tons . |
| Solid products | Bag of 1 kg ,2 kg ,5 kg ,25 kg ,500kg ,1000 kg . Drum of 25 kg and 50 kg. |
Packaging can be customized according to customer requirements.
Qingdao Jinyu Chemical Co., LTD,which is located in Qingdao City, China, with registered capital of RMB 10 million, is a dynamic chemical import and export enterprise with customer demand as its own responsibility. The founder has been engaged in the chemical industry for more than 20 years. With professional technical and marketing personnel, diversified cooperative factories with synthetic technology and efficient logistics management, we provide services to customers all over the world. After years of hard work, we have selected a number of excellent chemical production cooperative enterprises in China. These enterprises have their own advantages in different chemical synthesis fields. They have passed the strict inspection of suppliers by many customers and formed a long-term and stable strategic partnership with customers. With our partners' excellent equipment, well-trained employees and mature technology, we also continue to provide customers with more products.
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