| Customization: | Available |
|---|---|
| CAS No.: | 107-95-9 |
| Formula: | C3h7no2 |
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Basic Information
Product Name: β-Alanine
CAS Number:
Chemical Formula: C7H7NO2
Molecular Weight: 89.09 g/mol
β-Alanine is a non-proteinogenic amino acid that exists in a free form in living organisms and does not participate in protein synthesis. However, its metabolism and applications are of significant importance in fields such as biochemistry, medicine, and food science.
Main Sources
Biosynthesis
In mammals, β-alanine is primarily produced via uracil metabolism as an intermediate in pyrimidine nucleotide catabolism.
Certain bacteria (e.g., Escherichia coli) and plants can also synthesize β-alanine through specific pathways.
Dietary Sources
Higher concentrations are found in animal proteins such as meat and fish, while plant-based foods contain lower levels.
Humans can directly obtain β-alanine from diet or generate it through endogenous metabolism.
Physiological Functions
Precursor for Carnosine Synthesis
β-Alanine combines with histidine under enzymatic catalysis to form carnosine, which is widely distributed in muscles and the brain. Key roles include:
Antioxidation: Scavenging free radicals and reducing oxidative stress-induced cellular damage.
Acid-Base Buffering: Regulating muscle pH to delay fatigue caused by lactic acid accumulation during exercise, thereby enhancing exercise endurance (particularly effective in high-intensity interval training).
Neuroprotection: Possibly involved in antioxidant and anti-apoptotic processes in the nervous system.
Other Metabolic Roles
Participates in synthesizing anserine and carnosine analogs, which share similar functions with carnosine.
Serves as a precursor for cell wall components (e.g., peptidoglycan) in some bacteria.
Applications
1. Sports Nutrition and Health Supplements
Supplements: β-Alanine is a common ingredient in sports supplements, especially for enhancing muscle endurance and athletic performance.
Studies show that daily supplementation of 3-6 g β-alanine (administered in divided doses to avoid single-dose tingling) for several weeks significantly increases carnosine levels and prolongs the duration of moderate-to-high-intensity exercise.
Common forms: Powders, tablets, energy drinks, etc.
2. Pharmaceutical Field
Liver Disease Treatment: May participate in ammonia metabolism to assist in improving symptoms of hepatic encephalopathy (mechanism not fully clarified).
Cancer Research: As an intermediate in pyrimidine metabolism, its metabolic pathway may serve as a potential target for anticancer drugs.
Ophthalmic Applications: Topical use of β-alanine has been shown in some clinical studies to improve ocular surface cell function in dry eye patients.
3. Food and Feed Industry
Food Additives: Used as a flavoring agent (acidulant or flavor enhancer) in processed foods.
Feed Additives: Adding β-alanine to animal feed promotes growth (particularly effective in fish and poultry) and improves feed utilization.
4. Chemical and Biomedical Engineering
Serves as a raw material for synthesizing peptides and pharmaceutical intermediates (e.g., precursors for β-lactam antibiotics).
Used in the preparation of biodegradable materials (e.g., poly-β-alanine).
Safety and Precautions
Safety Profile
Generally safe at normal doses with no significant toxicity.
Approved as a food additive by both the European Food Safety Authority (EFSA) and the U.S. FDA.
Side Effects
Paraesthesia (Skin Tingling): Single doses exceeding 800 mg may cause transient tingling in the face, neck, or upper limbs due to histamine release, which is usually harmless and self-resolving.
Recommendation: Take in divided doses (e.g., ≤500 mg per dose, with 2-3-hour intervals) to reduce discomfort.
Contraindications
Individuals with renal insufficiency should exercise caution, as β-alanine is excreted by the kidneys and excessive intake may increase renal burden.
Limited safety data exist for pregnant/lactating women and children; additional supplementation is not recommended.
Research Advances and Prosp
| Liquid products | Drum of 5kg ,10 kg ,25 kg ,50 kg 200 kg ,250 kg . 1000 kg IBC drum. TANK with 20 tons ,25 tons . |
| Solid products | Bag of 1 kg ,2 kg ,5 kg ,25 kg ,500kg ,1000 kg . Drum of 25 kg and 50 kg. |
Packaging can be customized according to customer requirements.
Qingdao Jinyu Chemical Co., LTD,which is located in Qingdao City, China, with registered capital of RMB 10 million, is a dynamic chemical import and export enterprise with customer demand as its own responsibility. The founder has been engaged in the chemical industry for more than 20 years. With professional technical and marketing personnel, diversified cooperative factories with synthetic technology and efficient logistics management, we provide services to customers all over the world. After years of hard work, we have selected a number of excellent chemical production cooperative enterprises in China. These enterprises have their own advantages in different chemical synthesis fields. They have passed the strict inspection of suppliers by many customers and formed a long-term and stable strategic partnership with customers. With our partners' excellent equipment, well-trained employees and mature technology, we also continue to provide customers with more products.
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