| Customization: | Available |
|---|---|
| CAS No.: | 123333-53-9 ;2592-95-2 |
| Formula: | C6h5n3o.Xh2o |
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Basic Information
Product Name: 1-Hydroxybenzotriazole
Abbreviation: HOBt
CAS Number: 2592-95-2 for 1-Hydroxybenzotriazole, CAS 123333-53-9 for 1-Hydroxybenzotriazole hydrate
Molecular Formula: C6H5N3O;C6H5N3O.H2O
Molecular Weight: 135.13 g/mol
Appearance: White to off-white crystalline powder or crystals.
Melting Point: 159-162 °C (decomposes).
Solubility: Highly soluble in polar solvents such as water, ethanol, and acetone; slightly soluble in nonpolar solvents like diethyl ether.
Chemical Properties
Catalyst for Acylation Reactions:
Serves as a condensation additive in peptide synthesis (e.g., solid-phase peptide synthesis), often used in combination with carbodiimide reagents (e.g., DCC, EDC). It enhances reaction efficiency and reduces by-product formation (e.g., urea).
Mechanism: Forms an active intermediate (e.g., acyl-OBt ester) with carboxylic acids, promoting the coupling of amino and carboxyl groups while minimizing racemization.
Stability and Reactivity:
Stable at room temperature but decomposes when heated; should be stored away from light.
Weakly acidic with a pKa of approximately 8.1, forming corresponding salts (e.g., HOBt sodium salt) under basic conditions.
Applications
Drug and Peptide Synthesis:
Core use as an auxiliary reagent for peptide bond formation, widely applied in the research and production of peptide-based drugs such as antibiotics, hormones, and protein mimics.
Example: Improves yield and purity in synthesizing peptide drugs like insulin and somatostatin.
Organic Synthesis:
Used in amidation of carboxylic acids with amines and esterification of alcohols, especially for sterically hindered or low-reactivity substrates.
The EDC/HOBt system is a common combination in bioconjugation reactions (e.g., antibody-drug conjugates ADC).
Polymer Materials:
Acts as a catalyst or stabilizer in polymerization reactions for preparing polyamides, polyesters, and other polymers.
Safety Information
Toxicity: Low toxicity but irritating to skin, eyes, and respiratory tract; avoid direct contact.
Storage: Store in a sealed container in a cool, dry place, away from oxidizers and ignition sources.
Protection: Wear gloves and goggles during handling, operate in a fume hood, and avoid inhaling dust.
| Liquid products | Drum of 5kg ,10 kg ,25 kg ,50 kg 200 kg ,250 kg . 1000 kg IBC drum. TANK with 20 tons ,25 tons . |
| Solid products | Bag of 1 kg ,2 kg ,5 kg ,25 kg ,500kg ,1000 kg . Drum of 25 kg and 50 kg. |
Packaging can be customized according to customer requirements.
Qingdao Jinyu Chemical Co., LTD,which is located in Qingdao City, China, with registered capital of RMB 10 million, is a dynamic chemical import and export enterprise with customer demand as its own responsibility. The founder has been engaged in the chemical industry for more than 20 years. With professional technical and marketing personnel, diversified cooperative factories with synthetic technology and efficient logistics management, we provide services to customers all over the world. After years of hard work, we have selected a number of excellent chemical production cooperative enterprises in China. These enterprises have their own advantages in different chemical synthesis fields. They have passed the strict inspection of suppliers by many customers and formed a long-term and stable strategic partnership with customers. With our partners' excellent equipment, well-trained employees and mature technology, we also continue to provide customers with more products.
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