Factory Supply Sodium Cyanoborohydride CAS 25895-60-7

• Customization: Available
• CAS No.: 25895-60-7
• Formula: CH3bnna
• Model NO.: 99%
• Type: Synthesis Material Intermediates
• Appearance: Crystal
• Quality: Industrial
• Colour: White
• Specification: ≥ 99%
• Trademark: JinYu
• Origin: China

Product Description

Product Description

Basic Information

• Chemical Name: Sodium cyanoborohydride
• CAS Number: 25895-60-7
• Molecular Formula: NaBH3CN
• Molar Mass: 62.84 g/mol
• Appearance: White to off-white crystalline powder, hygroscopic
• Solubility: Highly soluble in water, methanol, and ethanol; slightly soluble in tetrahydrofuran (THF); insoluble in diethyl ether

Molecular Structure and Properties

• Structure: Composed of a cyanide group (-CN), a borohydride group (-BH3), and a sodium ion (Na). It is a cyano-substituted borohydride with strong reducing properties.
• Key Properties:
  • Reducing Ability: Exhibits strong reducibility under acidic conditions (pH < 4), commonly used in reductive amination reactions (e.g., converting aldehydes/ketones and amines into amines).
  • Stability:
    • Stable under basic conditions but slowly decomposes in acidic conditions, releasing hydrogen cyanide (HCN) gas (strict pH control is essential).
    • Gradually decomposes upon contact with water or moisture, generating boric acid, ammonia, and HCN; requires dry storage.
  • Toxicity: Highly toxic! The cyanide group (-CN) can release free cyanide ions (CN), which inhibit cytochrome oxidase, leading to tissue hypoxia and poisoning.

Applications

1. Organic Synthesis
   • Reductive Amination:
     • Aldehydes/ketones react with amines under acidic conditions to form imines (or ammonium ions), which are then reduced by sodium cyanoborohydride to amines. This is a common method for synthesizing secondary and tertiary amines.
     • Example: Synthesis of pharmaceutical intermediates (e.g., antidepressants, antibiotics).
   • Selective Reduction:
     • Prioritizes the reduction of imines/ammonium ions over aldehydes and ketones (compared to sodium borohydride), making it suitable for complex molecules with multiple functional groups.
2. Biochemistry and Medicine
   • Protein Modification: Used to modify aldehyde groups in proteins (e.g., glycosylation sites) for studying protein structure and function.
   • Radiolabeling: Serves as a reducing agent in nuclear medicine for labeling biomolecules (e.g., peptides, antibodies).
3. Other Uses
   • Metal surface treatment (e.g., as a reducing agent in gold/silver plating);
   • Reagent for cyanide ion detection in analytical chemistry (with strict safety precautions).
   •  

Safety and Handling Precautions

• High Toxicity:
  • Fatal if inhaled, contacted through skin, or ingested. Must be handled in a fume hood with protective gloves, goggles, and respiratory equipment (e.g., N95 mask or gas mask).
  • In case of leakage, cover with inert materials (e.g., sand), avoid contact with water, and dispose of by professionals.
• Reaction Control:
  • Avoid acidic conditions (pH < 4) to prevent HCN release; quench residual reagents with alkali solutions (e.g., NaOH) after reactions.
  • Reaction waste must be treated (e.g., oxidized with sodium hypochlorite) to destroy cyanide groups before hazardous waste disposal.
• Storage Requirements:
  • Store in a sealed container in a dry, cool place, away from water, acids, and oxidizing agents.
  •  

Comparison with Other Reducing Agents

Reducing Agent	Sodium Cyanoborohydride	Sodium Borohydride (NaBH4)	Lithium Aluminum Hydride (LiAlH4)
Reducing Strength	Moderate (acidic conditions)	Moderate (neutral/basic)	Strong (requires anhydrous conditions)
Selectivity	Prioritizes imines/ammonium ions	Reduces aldehydes, ketones, acyl chlorides	Reduces all reactive functional groups
Toxicity	Highly toxic (cyanide-containing)	Low toxicity (exothermic with water)	Highly reactive (explosive with water)
Common Reactions	Reductive amination	Reduction of aldehydes/ketones to alcohols	Deep reduction of complex molecules

Emergency Procedures

• Poisoning First Aid:
  • Move to fresh air immediately; maintain respiration. If breathing stops, provide artificial respiration (avoid mouth-to-mouth contact) and seek medical help immediately (antidotes: sodium nitrite-sodium thiosulfate combination therapy).
• Fire Fighting:
  • Do not use water; use dry powder or sand. Wear a gas mask when extinguishing fires.

Sodium cyanoborohydride is a highly efficient selective reducing agent in organic synthesis, but its extreme toxicity demands strict adherence to safety protocols. In laboratory and industrial applications, weigh its reaction advantages against safety risks and prioritize cyanide-free alternatives to minimize hazards.

Product Parameters

 

Packaging & Shipping

Liquid products	Drum of 5kg ,10 kg ,25 kg ,50 kg 200 kg ,250 kg . 1000 kg IBC drum. TANK with 20 tons ,25 tons .
Solid products	Bag of 1 kg ,2 kg ,5 kg ,25 kg ,500kg ,1000 kg . Drum of 25 kg and 50 kg.

Packaging can be customized according to customer requirements.

Company Profile

Qingdao Jinyu Chemical Co., LTD,which is located in Qingdao City, China, with registered capital of RMB 10 million, is a dynamic chemical import and export enterprise with customer demand as its own responsibility. The founder has been engaged in the chemical industry for more than 20 years. With professional technical and marketing personnel, diversified cooperative factories with synthetic technology and efficient logistics management, we provide services to customers all over the world. After years of hard work, we have selected a number of excellent chemical production cooperative enterprises in China. These enterprises have their own advantages in different chemical synthesis fields. They have passed the strict inspection of suppliers by many customers and formed a long-term and stable strategic partnership with customers. With our partners' excellent equipment, well-trained employees and mature technology, we also continue to provide customers with more products.

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