Quinolinic Acid Pyridine-2, 3-Dicarboxylic Acid CAS 89-00-9

• Customization: Available
• CAS No.: 89-00-9
• Formula: C7h5no4
• Model NO.: 99%
• Appearance: White Crystal
• Grade Standard: Industrial Grade
• Transport Package: 25 Kg Per Drum
• Specification: ≥ 99%
• Trademark: JinYu
• Origin: China

Product Description

Product Description

Basic Information

• Product Name: Pyridine-2,3-dicarboxylic acid
• Common Name: Quinolinic acid
• Chemical Formula: C7H5NO4
• Molecular Weight: 167.12 g/mol
• CAS Number: 89-00-9
• Appearance: White to light yellow crystalline powder
• Melting Point: 185-188 °C (decomposes)
• Solubility: Soluble in water (1.3 g/100 mL at 25°C), ethanol, and alkali solutions; slightly soluble in ether.

Physical and Chemical Properties
Structural Features

• The molecule consists of a pyridine ring with carboxylic acid groups at the 2- and 3-positions, giving it amphoteric properties (can act as both an acid and a base).

Chemical Reactivity

• Acidic Nature:
  • Dissociates in water to release hydrogen ions, with pKa values: ~2.4 (first carboxyl group), ~4.8 (second carboxyl group).
• Decarboxylation:
  • Heats above its melting point to decompose, releasing carbon dioxide (CO2) and forming pyridine-2-carboxylic acid (picolinic acid).
• Complexation:
  • Can act as a bidentate ligand, chelating metal ions (e.g., Zn², Cu²) through its carboxyl and nitrogen groups.

Biological Significance and Occurrence

1. Metabolic Intermediate
   • A key metabolite in the tryptophan degradation pathway in humans and animals, formed via the oxidation of 3-hydroxykynurenine by kynurenine 3-monooxygenase.
2. Neurotransmitter Role
   • Functions as an excitatory neurotransmitter in the central nervous system, acting at NMDA receptors. Elevated levels are associated with neurodegenerative diseases (e.g., Huntington's disease, Alzheimer's disease).
3. Natural Occurrence
   • Found in small amounts in foods like brewer's yeast, rice, and some vegetables, as well as in biological fluids (blood, urine).

Applications

1. Pharmaceutical Research
   • Drug Intermediate: Used in synthesizing antiviral agents, antitumor drugs, and NMDA receptor modulators.
   • Neurodegenerative Disease Studies: Serves as a tool to model excitotoxicity in research on Huntington's and related disorders.
2. Organic Synthesis
   • Precursor for synthesizing heterocyclic compounds (e.g., quinoline derivatives, pyridine-based ligands for coordination chemistry).
3. Analytical Chemistry
   • Used as a standard in HPLC and as a chelating agent for metal ion analysis.
4. Agriculture
   • Intermediate in the production of certain herbicides and plant growth regulators.

Safety and Handling

• Toxicity:
  • Low acute toxicity (oral LD50 in rats: >2000 mg/kg), but may cause skin/eye irritation.
  • Inhalation of dust irritates the respiratory tract; prolonged exposure to high concentrations may pose health risks.
• Storage and Precautions:
  • Store in a cool, dry, well-ventilated area, away from strong oxidizers and bases.
  • Use gloves and goggles when handling; avoid inhaling dust or contact with skin.
• Environmental Impact:
  • Degrades in water and soil under aerobic conditions; low persistence but may affect aquatic life at high concentrations.

Product Parameters

 

Packaging & Shipping

Liquid products	Drum of 5kg ,10 kg ,25 kg ,50 kg 200 kg ,250 kg . 1000 kg IBC drum. TANK with 20 tons ,25 tons .
Solid products	Bag of 1 kg ,2 kg ,5 kg ,25 kg ,500kg ,1000 kg . Drum of 25 kg and 50 kg.

Packaging can be customized according to customer requirements.

Company Profile

Qingdao Jinyu Chemical Co., LTD,which is located in Qingdao City, China, with registered capital of RMB 10 million, is a dynamic chemical import and export enterprise with customer demand as its own responsibility. The founder has been engaged in the chemical industry for more than 20 years. With professional technical and marketing personnel, diversified cooperative factories with synthetic technology and efficient logistics management, we provide services to customers all over the world. After years of hard work, we have selected a number of excellent chemical production cooperative enterprises in China. These enterprises have their own advantages in different chemical synthesis fields. They have passed the strict inspection of suppliers by many customers and formed a long-term and stable strategic partnership with customers. With our partners' excellent equipment, well-trained employees and mature technology, we also continue to provide customers with more products.

Our Advantages