| Customization: | Available |
|---|---|
| CAS No.: | 532-43-4 |
| Formula: | C12h17n5o4s |
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Basic Information
Product Name: Thiamine Nitrate
Other Names: Vitamin B1 Nitrate, Thiamine Mononitrate
Chemical Formula: C12H17N5O4S.HNO3
Molecular Weight: 373.38 (may vary slightly with water of crystallization)
CAS Registry Number: 532-43-4
Appearance: White to slightly yellow crystalline powder, with a faint characteristic odor
Solubility: Soluble in water, slightly soluble in ethanol, insoluble in ether or benzene
Stability: Stable in acidic solutions, easily decomposed in alkaline conditions, prone to deterioration upon light exposure
Melting Point: Approximately 196-200°C (decomposes)
Hygroscopicity: Hygroscopic; stable in dry conditions but prone to decomposition in humid environments.
Chemical Characteristics: A nitrate salt form of thiamine (vitamin B1), biologically active and converted to thiamine pyrophosphate (TPP)-its active form-in the body, participating in glucose metabolism.
Physiological Functions and Roles
As a stable derivative of vitamin B1, thiamine nitrate exerts the following effects after metabolism:
Involvement in Glucose Metabolism
Thiamine pyrophosphate (TPP) acts as a coenzyme for pyruvate dehydrogenase complex and α-ketoglutarate dehydrogenase complex, catalyzing key steps in glucose metabolism (e.g., conversion of pyruvate to acetyl-CoA) to ensure normal energy production.
Deficiency leads to glucose metabolism disorders, insufficient energy supply to neural tissues and myocardium, and the development of beriberi.
Maintenance of Nervous System Function
Promotes the synthesis of neurotransmitters (e.g., acetylcholine) and maintains nerve impulse transmission. Deficiency may cause peripheral neuritis symptoms such as numbness, paresthesia, and neuralgia.
Protection of the Cardiovascular System
Improves myocardial energy metabolism and maintains normal cardiac function. Severe deficiency can lead to high-output heart failure (wet beriberi).
Promotion of Gastrointestinal Motility
Enhances gastrointestinal smooth muscle tone and digestive gland secretion. Deficiency may cause loss of appetite and indigestion.
Clinical Applications
Prevention and Treatment of Vitamin B1 Deficiency
Indicated for beriberi, Wernicke encephalopathy (alcohol-related encephalopathy), and vitamin B1 deficiency during pregnancy or lactation.
Treatment doses are typically administered orally or intramuscularly, adjusted according to the condition.
As a Nutritional Supplement
Added to foods (e.g., infant formula, cereal products), health products, or compound vitamin preparations to prevent deficiency due to inadequate intake.
Other Adjuvant Therapies
Used in chronic alcoholism, long-term hemodialysis, and gastrointestinal diseases (e.g., short bowel syndrome) where vitamin B consumption increases or absorption is impaired.
Adverse Reactions and Precautions
Adverse Effects
Generally safe at normal doses; rare allergic reactions (e.g., rash, itching) may occur.
Rapid intravenous injection may cause dizziness, nausea, or arrhythmia, so oral or intramuscular administration is preferred.
Contraindications and Cautions
Contraindicated in: Individuals allergic to thiamine or this product.
Use with Caution in: Pregnant and lactating women (requires medical guidance); patients with megaloblastic anemia (may mask concurrent folate or vitamin B12 deficiency).
Drug Interactions
Alkaline drugs (e.g., sodium bicarbonate, sodium citrate) may destroy its stability; avoid concurrent use.
Tannin-containing Chinese herbs (e.g., Galla Chinensis, Radix Sanguisorbae) may form precipitates with thiamine nitrate, reducing absorption.
Storage and Preparation
Storage Conditions: Store in a cool, dry place, protected from light and moisture, away from high temperatures.
Formulations: Common preparations include tablets, injectables (e.g., injection solutions), and compound vitamin formulations (e.g., Compound Vitamin B Injection).
| Liquid products | Drum of 5kg ,10 kg ,25 kg ,50 kg 200 kg ,250 kg . 1000 kg IBC drum. TANK with 20 tons ,25 tons . |
| Solid products | Bag of 1 kg ,2 kg ,5 kg ,25 kg ,500kg ,1000 kg . Drum of 25 kg and 50 kg. |
Packaging can be customized according to customer requirements.
Qingdao Jinyu Chemical Co., LTD,which is located in Qingdao City, China, with registered capital of RMB 10 million, is a dynamic chemical import and export enterprise with customer demand as its own responsibility. The founder has been engaged in the chemical industry for more than 20 years. With professional technical and marketing personnel, diversified cooperative factories with synthetic technology and efficient logistics management, we provide services to customers all over the world. After years of hard work, we have selected a number of excellent chemical production cooperative enterprises in China. These enterprises have their own advantages in different chemical synthesis fields. They have passed the strict inspection of suppliers by many customers and formed a long-term and stable strategic partnership with customers. With our partners' excellent equipment, well-trained employees and mature technology, we also continue to provide customers with more products.
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